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About CLAs


There is no standard approach for treatment for CLAs. Treatment is often aimed at reducing and easing symptoms. A multidisciplinary, team approach to care and treatment is highly recommended and often necessary.

Medications that have been commonly used to treat CLAs include:

  • Sirolimus
  • Alpelisib
  • Interferon-alfa 2a or 2b
  • Bisphosphonates


Patients with chylous (lymph fluid with fat) effusions may be prescribed a low-fat diet.

Patients treated with Sirolimus or Alpelesib may be prescribed a low carbohydrate diet as both medications tend to raise blood sugar

Other treatments include interventional radiology and surgery.