Skip to main content
Patients & Caregivers

Pre-Clinical Models 101: Research Models & How They Are Used to Study CLAs

Timothy LeCras, PhD

University of Cincinnati Department of Pediatrics Cincinnati, OH, USA

The goal of my research program is to investigate the mechanisms underlying vascular anomalies in children and adults. I have been working in the field of vascular biology and disease for over 30 years and have extensive expertise studying the molecular and cellular pathways underlying human diseases. More recently my work has focused on the role of vascular growth factors and gene mutations in human endothelial cells and how they contribute to the pathogenesis of vascular anomalies. The strength of our research is the use of human cells and samples to determine signaling pathways, identify disease biomarkers and test potential novel targeted therapies. I collaborate with physicians and other scientists both at Cincinnati Children’s and other major medical centers who are world-experts in the investigation and treatment of vascular anomalies.

Michael Dillinger, PhD
University of Texas Southwestern Medical School, Dallas, TX, USA

Dr. Michael Dellinger is an Assistant Professor in the Departments of Surgery and Molecular Biology at UT Southwestern Medical Center. He is also the Director of Research for the Lymphatic Malformation Institute. Dr. Dellinger completed his Ph.D. work at the University of Arizona and his postdoctoral studies at UT Southwestern Medical Center. His lab is focused on identifying biomarkers and treatments for complex lymphatic anomalies.