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Researchers & Clinicians

CLA Conference Agenda

Updated: July 18, 2023

For a detailed agenda, click here.

September 29

BASIC SCIENCE SESSION: GENETIC CAUSES OF COMPLEX LYMPHATIC ANOMALIES 
Genetic of CLAs 
Miikka Vikkula, MD, PhD, Professor of Human Genetics and Co-Director de Duve Institute, Université catholique de Louvain, Brussels, Belgium 

Expanded Genetic Causes in CLAs using Ultra-Deep Sequencing and Unconventional Samples
Dong Li, PhD, Assistant Professor of Pediatrics
University of Pennsylvania, Center for Applied Genomics and Children's Hospital of Philadelphia, Pennsylvania, USA

Detection of PIK3CA Mutations in Aspirated Cyst Fluid is Comparable to Surgically Resected Tissues: Minimally Invasive Diagnostics for Lymphatic Malformations James Bennett, MD, PhD, Associate Professor
Department of Pediatrics, Division Genetic Medicine, University of Washington and Vascular Anomalies Program, Seattle Children's Hospital and Center for Development Biology and Regenerative Medicine, Seattle Children's Research Institute, Washington, USA

Targeting Proteostasis Defects Downstream of PI3K/mTOR Hyperactivation in Lymphatic Anomalies 
Carrie Shawber, PhD,  Associate Professor of Reproductive Sciences
Departments of OBGYN and Surgery, Columbia University Irving Medical Center, New York, USA 

Matching Genetic Variant with Appropriate Medical Therapy – Proposed VATCH Clinical Trial 
Alex Borst, MD, Assistant Professor of Pediatrics, Penn Medicine and the Hemostasis and Thrombosis Center at Children's Hospital of Philadelphia, Pennsylvania, USA


September 30 

CLINICAL SESSION:  PATIENT CENTERED RESEARCH AND REGISTRIES 
Visualizing the Lymphatic Vessels and Flow with High-Resolution Ultrasound and Microvascular Flow Imaging* 
Willemijn M. Klein, MD, PhD  
Department of Medical Imaging Radiology, Radboud University Medical Center Nijmegen, NL 

KLA: Update from the BCH Registry
Whitney Eng (Seattle Children's Hospital, USA) 

Complex Lymphatic Anomalies: Report on a Patient Registry Using the Latest Diagnostic Guidelines 
Jochen Rössler  
University Hospital Bern, Pediatric Hematology and Oncology, Switzerland  

BASIC SCIENCE SESSION: PRECLINICAL MODELS OF CLAs 

Zebrafish Models of CCLA Due to Ras GTPases  
Sarah Sheppard, MD, PhD, MSTR, Clinical Investigator 
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maryland USA

Role of NRAS Q61R in the Pathogenesis of Kaposiform Lymphangiomatosis 
Tim D. Le Cras, PhD  
Professor of Pediatrics, Associate Dean for Graduate Education
University of Cincinnati & Cincinnati Children’s Hospital  

Cellular Mechanisms Underlying PIK3CA-driven Lymphatic Anomalies
Hans Schoofs Uppsala University, Sweden 

The Role of Hyperactive KRAS Signaling in Complex Lymphatic Anomalies
Mike Dellinger
UT Southwestern Medical Center, Texas, USA 

2022 Young Investigator Awardees 

Analysis of a New Therapeutic Approach to Inhibit Osteolysis in Gorham-Stout Disease 
Michela Rossi, PhD 
Bone Physiopathology Research Unit, Translational Pediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy      Mentor: Andre Del Fattore 

Molecular Mechanisms of EPHB4 Pathogenesis – Towards New Treatment Development for Lymphatic Anomalies   
Silvia Martin Almedina, PhD  
Molecular and Clinical Sciences Institute, St George’s University of London, UK         
Mentor: Pia Ostergaard 

CLINICAL SESSION:  CLINICAL ADVANCES 

Treatment of CLAs – overview  
Kiersten Ricci (Cincinnati Children’s Hospital Medical Center, USA) 

Lymphatic Effusions in Infancy
Ionela Iacobas
Texas Children's Hospital and Baylor College of Medicine, Texas, USA 

Spectrum of Gorham-Stout Disease Exploring a Single Center Pediatric Case Series  
Sabrina Buonuomo, MD and Ippolita Rana, MD   
Rare Disease and Medical Genetics, Bambino Gesù Children’s Hospital, IRCCS Rome, Italy 

Experience in the Use of Alpelisib in Patients with Vascular Anomalies    
Paloma Triana, MD 
Pediatric surgery, Children's Hospital La Paz 

BASIC SCIENCE SESSION: NEW TECHNOLOGIES FOR CLA RESEARCH

HAM, A Novel Pleurodesis Agent Inspired by PAM for LAM     
Frank McCormack, Professor and Director of Plumonary, Critical Care, and Sleep Medicine University of Cincinnati, Ohio, USA 

Engineering Approaches for Understanding Cellular Dynamics in GLA 
William Polacheck, Assistant Professor of Biomedical Engineering
University of North Carolina at Chapel Hill, North Carolina, USA 

Leveraging Tissue Engineered Lymphatic Malformation Models and Patient Genomics to Study Response to Medical Therapy  
Brandon Dixon, Professor
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Georgia, USA) 

CLINICAL SESSION:  ADVANCES IN IMAGING OF CLAS

Integrative Diagnostic Imaging of Tissue Biopsies for Spatial Deep-phenotyping of Lymphatic Anomalies  
Rene Haegerling, Clinical Geneticist and Research Group Leader
Charité – Universitätsmedizin Berlin and Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany   

Interventions in Complex Lymphatic Anomalies: Current and Future Directions   
Deb Rabinowitz, MD, Interventional Radiology, Division Chief and Nemours Lymphatics Disease Program, Director 
Nemours Children’s Hospital-Delaware, Delaware, USA

Communication, Health Care Delivery, and Burdens of Disease in Complex Lymphatic Anomalies*
Bryan Sisk, MD  
Assistant Professor, Pediatric Hematology and Oncology Director of Research, Bioethics Research Center, Co-Director, Vascular Anomalies Center, Washington University School of Medicine  

*Drs. Bryan Sisk and Willemijn Klein presentations switched time slots from previous agenda.

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