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2023 CLA Conference

Diagnostic Imaging of Tissue Biopsies for Spatial Deep-phenotyping of Lymphatic Anomalies

In the ever-evolving world of medical diagnostics, a groundbreaking approach is changing the game. Join us as we delve into the fascinating realm of 3D histology and integrative diagnostics.

In this video, we explore the limitations of traditional 2D histology and how the missing spatial information can hinder our understanding of complex conditions like cancer and rare diseases. We'll walk you through the birth of 3D histology, a revolutionary approach that combines traditional histology with advanced imaging technology. With the help of a light-sheet microscope, we can now visualize tissue samples in all three dimensions, providing us with a more comprehensive view of the tissue microenvironment.

But that's not all! We introduce you to the superheroes of immunostaining – nanobodies. These single-domain antibodies, derived from llamas and alpacas, are changing the game in diagnostic accuracy. We show you how nanobodies enhance the quality and specificity of our 3D reconstructions.

The magic happens when we put it all together – 3D histology and integrative diagnostics. Learn how we can perform next-generation sequencing (NGS) on the same tissue sample used for 3D histology. This integrated approach provides a deeper understanding of diseases, enabling more accurate diagnoses and personalized treatment plans.