Genetics of CLAs

Dr. Miikka Vikkula discusses the classification of lymphatic anomalies into various categories, including lymphedemas and lymphatic malformations. He explains that lymphedemas can be further categorized based on clinical presentation, age of onset, and association with other organ systems. The presentation delves into the genetic basis of these anomalies, exploring germline and somatic mutations in various genes, and emphasizing the need for expanded research in this area. He also touches upon potential therapeutic strategies and the importance of early treatment, highlighting a case involving in utero treatment for a fetal lymphatic malformation.