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2023 CLA Conference

HAM, A Novel Pleurodesis Agent Inspired by PAM for LAM

Join us on a fascinating journey through the world of rare lung diseases as we explore groundbreaking research and discoveries that have the potential to change lives. In this video, we delve into the enigmatic realm of Lymphangioleiomyomatosis (LAM) and its unexpected connection to osteoclasts, bone-resorbing cells, in the context of pulmonary alveolar microlithiasis (PAM).

Lymphangioleiomyomatosis (LAM) - An Introduction: Discover the intricacies of LAM, a rare lung disease primarily affecting women. Learn how LAM cells express specific markers, making them invaluable for diagnosis, and explore the role of ceramides in stabilizing lung function for LAM patients.

A New Perspective - LAM's Origin: Witness the groundbreaking single-cell RNA sequencing experiment that sheds light on the origin of LAM cells, hinting at a surprising connection to the uterus. Explore the intriguing pathogenesis of LAM, leading to cyst formation and lung destruction.

Ceramides - A Ray of Hope: Uncover the transformative impact of ceramide-based therapy (sirolimus) in managing LAM. See how it has revolutionized the treatment landscape, offering hope and improved quality of life for patients. Challenges with Recurrent Pneumothorax: Despite advancements, recurrent pneumothorax remains a significant challenge in LAM management. Learn about talc pleurodesis and the quest for a safer alternative.

Osteoclasts in Lung Pathology: Venture into uncharted territory as we explore the unexpected role of osteoclasts in lung pathologies. Discover how talc and hydroxyapatite particles induce osteoclast differentiation in the pleural space, contributing to particle degradation and fibrosis.

Hydroxyapatite - A Potential Alternative: Could hydroxyapatite be the answer to safer and more effective pleurodesis? Explore its promising potential as an alternative to talc, addressing long-standing concerns and providing hope for patients.

Future Directions: Look ahead to the future of research in rare lung diseases. Learn about ongoing experiments, animal models, and the journey toward seeking FDA approval for clinical trials.

Our ultimate goal: to transform pulmonary medicine and improve patient care. Join us in this captivating exploration of rare lung diseases, where science and discovery come together to offer hope, relief, and a brighter future. Don't miss this eye-opening journey—watch now!