In this research seminar, Griffin McDaniel, MD-PhD student at Cincinnati Children’s Hospital, presents groundbreaking work on developing mouse models for Kaposiform Lymphangiomatosis (KLA)—a rare, life-threatening complex lymphatic anomaly. Funded in part by the Alfie Milne Young Investigator Award, Griffin explores the role of NRAS Q61R mutations in disease progression using both in vitro endothelial cell systems and two genetic in vivo mouse models.
Watch as Griffin discusses:
The clinical features and diagnostic challenges of KLA
How NRAS mutations drive spindled cell morphology and angiopoietin-2 production
The development of postnatal and embryonic mouse models that mirror key features of KLA
Implications for future drug screening and targeted therapies
The session concludes with an engaging Q&A with experts in the field. This presentation is essential viewing for researchers, clinicians, and advocates working in vascular anomalies and rare disease research.
